| 摘要 |
An N-(3-pyrrolidinyl)benzamide derivative represented by general formula (I) having a selective and potent affinity for dopamine D3 receptors and/or dopamine D4 receptors, a pharmaceutically acceptable salt thereof, and dopamine D3 receptor and/or dopamine D4 receptor antagonists, wherein R<1> represents halogen; R<2> represents lower alkoxy; R<3> represents hydrogen or lower alkyl; A represents a single bond or lower alkylene; ring B represents substituted or unsubstituted: 1) saturated or unsaturated 3- to 8-membered monocyclic hydrocarbon groups or 4- to 16-membered fused bicyclic hydrocarbon groups; 2) saturated or unsaturated 3- to 8-membered heterocyclic group or 6- to 16-membered fused bicyclic heterocyclic group each containing one or two of the heteroatoms comprising nitrogen, sulfur and oxygen, 3) saturated or unsaturated 4- to 16-membered bi- or tricyclic bridged hydrocarbon group, or 4) saturated or unsaturated 6- to 16-membered bi- or tricyclic bridged heterocyclic group each containing one or two of the heteroatoms comprising nitrogen, sulfur and oxygen; and R<4> represents 1) phenyl; 2) halogenated or nonhalogenated 3- to 8-membered monocyclic saturated hydrocarbon group; or 3) lower alkyl, halogenated lower alkyl or lower alkenyl; provided with group -A-B represents benzyl, R<4> represents a group other than methyl. This compound is useful as a psychotropic agent having little or no side effects such as extrapyramidal syndrome. |
