| 发明名称 |
ENDOTHELIN ANTAGONISTS INCORPORATING A CYCLOBUTANE |
| 摘要 |
Novel compounds of general structural formula (I) have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, inflammatory diseases including Raynaud's disease and asthma.
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| 申请公布号 |
WO9508989(A1) |
申请公布日期 |
1995.04.06 |
| 申请号 |
WO1994US10822 |
申请日期 |
1994.09.23 |
| 申请人 |
MERCK & CO., INC.;RIVERO, RALPH, A.;VEBER, DANIEL, F.;WILLIAMS, PETER, D. |
发明人 |
RIVERO, RALPH, A.;VEBER, DANIEL, F.;WILLIAMS, PETER, D. |
| 分类号 |
C07C33/36;C07C45/45;C07C49/697;C07C62/38;C07C69/00;C07C235/82;C07D295/185;(IPC1-7):A61K31/18;A61K31/325;A61K31/445;C07C59/40;C07C50/36;C07C59/84;C07C59/86;C07C62/30;C07C62/36;C07C63/33;C07C63/34;C07C65/30;C07C65/34;C07C69/76;C07C69/95;C07C205/06;C07C229/38;C07C317/12;C07C317/14;C07C321/00;C07C321/02;C07D211/30;C07D211/32;C07D211/60 |
主分类号 |
C07C33/36 |
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