PROCESS AND INTERMEDIATES FOR THE ENANTIOSPECIFIC SYNTHESIS OF BENZO [D]NAPHTH[2,1-B]AZEPINES

摘要

Disclosed are a process and intermediates of formula (1) wherein R is -CH3 or -C(O)-OR<1>, and R<1> is C1-C6 alkyl or -CH2C6H5; or formula (2) wherein: R<2> is H or OH, R is -C(O)OR<1> and R<1> is C1-C6 alkyl or -CH2C6H5, or where R<2> is H, R can also be CH3; for preparing benzazepine intermediates of formula (3). The benzazepine intermediates are useful for preparing benzazepines having activity as selective D1 receptor antagonists.