摘要 |
Disclosed are DNA sequences encoding deletion, substitution and/or addition analogs of the E. coli enzyme, chorismate mutase/prephenate dehydratase (CMPD). Preferred expression products include [des-Gln<3><0><7>, des-Ala<3><0><8>, des-Gly<3><0><9>, des-Ala<3><1><0>]CMPD; [Leu<3><0><6>]CMPD; [des-Thr<3><0><4>, Lys<3><0><5>, des-Gln<3><0><6>]CMPD; and [Cys<3><0><9>]CMPD display enzymatic activity of the wild type enzyme but are more resistant to inhibition in the presence of phenylalanine. |
申请人 |
THE NUTRASWEET CO., DEERFIELD, ILL., US |
发明人 |
FOTHERINGHAM, IAN GRAHAM,, WHEELING, ILLINOIS 60090, US;NELMS, JENNIFER,, DES PLAINES, ILLINOIS 60016, US |