METHODS AND COMPOSITIONS FOR TREATMENT OF BCR-ABL ASSOCIATED LEUKEMIAS AND OTHER CELL PROLIFERATIVE DISORDERS
摘要
The present invention relates to compositions and methods for the prevention and treatment of cell proliferative disorders wherein a protein tyrosine kinase or protein tyrosine phosphatase capable of complexing with a member of the SH2- and/or SH3 domain-containing family of adaptor proteins is involved. This invention is based, in part, on the surprising discovery that the adaptor protein, GRB-2, binds the intracellular BCR-ABL tyrosine kinase product in vivo and is necessary for the activation of the oncogenic potential of the BCR/ABL product. The present invention further relates to protein tyrosine kinase/adaptor protein complexes and the uses of these complexes for the identification of agents capable of decreasing or inhibiting the interaction between the members of such complexes.
申请公布号
WO9509365(A1)
申请公布日期
1995.04.06
申请号
WO1994US11067
申请日期
1994.09.28
申请人
NEW YORK UNIVERSITY MEDICAL CENTER;SUGEN, INC.;DUKE UNIVERSITY MEDICAL CENTER;SCHLESSINGER, JOSEPH;GISHIZKY, MIKHAIL, L.;PENDERGAST, ANN, M.;APP, HARALD
发明人
SCHLESSINGER, JOSEPH;GISHIZKY, MIKHAIL, L.;PENDERGAST, ANN, M.;APP, HARALD