ESTRADIOL DERIVATIVE-ALKYLATING AGENT CONJUGATE WITH REDUCED HORMONAL ACTIVITY, PROCESS FOR PREPARING THE SAME, COMPOUNDS USEFUL FOR THE PREPARATION THEREOF, AND GROWTH INHIBITINGCOMPOSITION CONTAINING THE CONJUGATE OR ESTRADIOL DERIVATIVE

摘要

Disclosed is an estradiol derivative-alkylating agent conjugate of the formula (I'): <IMG> (I') wherein R1 is C1-4 alkyl or C1-4 alkoxy; R2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of 0 to 3, as a growth inhibiting agent.