| 摘要 |
<p>The invention provides a composition of matter, comprised of certain oligonucleotides, which inhibit the expression of β/A4 peptide of Alzheimer's disease and Down's Syndrome, and nerve growth factor (NGF) to reverse morphological changes caused in neuronal cells by β/A4 peptide. Further, pharmaceutical compositions, kits and methods for treatment of β/A4 amyloid-induced morphology as well as an assay for screening candidate antisense oligonucleotides effective in treatment of deleterius effects that are visited upon cells by β/A4 amyloid peptide are described.</p> |
