| 摘要 |
The invention relates to tricyclic derivatives of formula (I), wherein R<1> includes hydrogen, amino, (1-4C)alkyl and (1-4C)alkoxy; R<2> includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl and (3-4C)alkynyl; Ar<1> is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and Ar<2> is optionally-substituted phenyl or heteroaryl; or a pharmaceutically-acceptable salt thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as thymidylate synthase inhibitors.
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