INCREASING AQUEOUS HUMOR OUTFLOW

摘要

A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma, the method comprising topically administering to the eye an outflow-increasing amount of an analog of ethacrynic acid having a margin of safety of at least 2.0 and having formula (I), wherein each X1 and X2, independently, is a halogen, H, or CH3, or X1 and X2 together form a substituted or unsubstituted aromatic ring; X3 is an organic group; and X4 is OH or an organic group; provided that where X1 and X2 are Cl and X4 is OH, X3 cannot be 2-methylene-1-oxobutyl; or a pharmaceutically acceptable salt thereof.