发明名称 |
METHODS AND COMPOSITIONS FOR TREATMENT OF BCR-ABL ASSOCIATED LEUKEMIAS AND OTHER CELL PROLIFERATIVE DISORDERS |
摘要 |
The present invention relates to compositions and methods for the prevention and treatment of cell proliferative disorder wherein a protein tyrosine kinase or protein tyrosine phosphatase capable of complexing with a member of the SH2- and/or SH3 domain-containing, family of adaptor proteins is involved. This invention is based, in part, on the surprising discovery that the adaptor protein, GRB-2, binds the intracellular BCR-ABL tyrosine kinase product in vivo and is necessary for the activation of the oncogenic potential of the BCR/ABL product. The present invention further relates to protein tyrosine kinase/adaptor protein complexes and the uses of these complexes for the identification of agents capable of decreasing or inhibiting the interaction between the members of such complexes.
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申请公布号 |
CA2172961(A1) |
申请公布日期 |
1995.04.06 |
申请号 |
CA19942172961 |
申请日期 |
1994.09.28 |
申请人 |
NEW YORK UNIVERSITY MEDICAL CENTER, SUGEN, INC.;SUGEN, INC.;DUKE UNIVERSITY MEDICAL CENTER |
发明人 |
SCHLESSINGER, JOSEPH;GISHIZKY, MIKHAIL L.;PENDERGAST, ANN M.;APP, HARALD |
分类号 |
A61K38/00;A61K45/00;C07K14/47;C07K14/82;C12N15/09;C12Q1/48;G01N33/50;G01N33/53;G01N33/536;G01N33/566;G01N33/573;G01N33/574;G01N33/68;(IPC1-7):G01N33/566;A61K39/395 |
主分类号 |
A61K38/00 |
代理机构 |
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