METHOD OF PREPARING OPTICALLY ACTIVE HOMO-BETA-AMINO ACIDS

摘要

The present invention is directed to synthesis of homo- beta -amino acids of an optical purity sufficient to exhibit optical activity wherein Curtius rearrangement of 3-mono-substituted succinate acid half ester of an optical purity sufficient to exhibit optical activity is affected and the incipient isocyanate is trapped with a primary or secondary alcohol. The resulting carbamate-protected homo- beta -amino esters are then saponified to produce the corresponding carbamate-protected homo- beta -amino acids which are deprotected to yield homo- beta -amino acids of an optical purity sufficient to exhibit optical activity.