| 摘要 |
<p>Cpds. (I) and their salts (where B is R1 is H or 1-6C alkyl, 7-10C aralkyl or aroyl, R2 is H, 1-6C alkyl or aryl, R3 is H, halogen, 1-6C alkoxy, OH or 1-6C alkyl, R4 is H or halogen, or 1-6C alkyl, R5 is 5-7C cycloalkyl, X circled negative is an anion, and A is alkylene, mono- or di-ketoalkylene of up to 4C) are prepd. either by reacting a 3-haloalkyl indole with an acylated aminoheterocyclic cpd. or by acylating the free amino group on the heterocyclic ring in a cpd. derived from (I) or by reducing a cpd. (I) where the heterocyclic ring is unsatd. or by a Fisher indole synthesis. Thus 3- 2-(4-cyclohexanecarbonamido-1-piperidyl)ethyl indole is prepd. from 3-(2-bromethyl)indole and 4-cyclohexanecarboxamidopiperidine.</p> |
