| 摘要 |
<p>A method of obtaining a high purity immunoglobulin preparation from an antibody rich colostrum which includes: (i) removing milk fat from the colostrum to obtain a low-fat colostrum; (ii) pasteurising the low-fat colostrum; (iii) coagulating the pasteurised, low-fat colostrum and removing milk curd containing casein; (iv) centrifuging remaining liquid to remove percipitates; (v) removing lactose, minerals and water to obtain an antibody containing fraction; (vi) dissolving the antibody containing fraction in THRESH buffer and idolizing against the same buffer; and (vii) concentrating the antibody containing solution to obtain a 10 % by weight antibody solution. A pharmaceutical composition including a core element which includes an active antibody component derived by the above method, wherein the core element is in the form of a tablet, and wherein the compression forces used to prepare the tablet are such that they do not injure or denature the active antibodies.</p> |
