MONOCLONAL ANTIBODIES AGAINST LEUKOCYTE-SPECIFIC G-PROTEIN-COUPLED RECEPTORS
摘要
Monoclonal antibodies against leukocyte-specific G-protein-coupled receptors (L-GCR) are disclosed. These antibodies may be produced by the following steps: (a) introduction of a L-GCR coding nucleic acid into cells and expression of L-GCR; (b) immunisation of animals with L-GCR-expressing cells (a); and (c) fusion of spleen cells from the immunised animals (b) with myeloma cells and production of monoclonal L-GCR antibody-producing hybridoma cells. Also disclosed is a process for producing such antibodies, their use and kits containing the same, as well as a process for producing monoclonal GCR antibodies.
申请公布号
WO9508576(A1)
申请公布日期
1995.03.30
申请号
WO1994EP03175
申请日期
1994.09.22
申请人
LIPP, MARTIN;FOERSTER, REINHOLD;EMRICH, THOMAS;WOLF, INGRID;KREMMER, ELISABETH
发明人
LIPP, MARTIN;FOERSTER, REINHOLD;EMRICH, THOMAS;WOLF, INGRID;KREMMER, ELISABETH