INTERACTION OF T-CELL RECEPTORS AND ANTIGEN IN AUTOIMMUNE DISEASE

摘要

Methods are provided for determining relations between autoimmune degenerative diseases and specific variable regions of T-cell receptors as associated with the host HLA or T cells associated with combatting neoproliferative diseases. By identifying the particular T-cell receptors which cause or are the disease in mammals, various prophylactic and thereapeutic techniques may be employed for inhibiting the attack of the T-cell receptors on the native protein or tissue to enhance the defense. In addition, individuals may be diagnosed as to their propensity for a particular autoimmune disease or the occurrence of such a disease.