METHOD OF TREATING GRAM-NEGATIVE BACTERIAL INFECTION BY ADMINISTRATION OF BACTERICIDAL/PERMEABILITY-INCREASING (BPI) PROTEIN PRODUCT AND ANTIBIOTIC

摘要

The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasing antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.