METHOD OF TREATING GRAM-NEGATIVE BACTERIAL INFECTION BY ADMINISTRATION OF BACTERICIDAL/PERMEABILITY-INCREASING (BPI) PROTEIN

摘要

The present invention relates to methods and compositions for treating gram- negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasi ng antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.