METHOD OF ACTIVATING SOLUBLE CARBOHYDRATE USING NOVEL CYANYLATING REAGENTS FOR THE PRODUCTION OF IMMUNOGENIC CONSTRUCTS

摘要

A process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with a novel cyanylating reagent and covalently joining said activated first moiety to a second moiety. Immunogenic constructs may be prepared by this process using either direct conjugation of first and second moieties or using indirect conjugation with a bifunctional reagent.