摘要 |
A process for stereoselective (enantioselective) production of S-(-)-fenpropimorph, which process comprises reacting 4-tert-butylbenzylchloride or bromide with methyldiethylmalonate, decarbethoxylation of the product into racemic 3-(4-tert-butylphenyl)-2-methylpropionic acid ethyl ester in DMSO in the presence of alkali cations, then Pseudomonas sp. lipase catalyzed resolution of racemic ester to S-(-)-acid, base-catalyzed racemisation and recycling of the R-(+)-ester, acylation of cis-2,6-dimethylmorpholine with the activated derivative of S-(-)-acid, and final reduction of the intermediary amide to provide optically (enantiomerically) pure S-(-)-fenpropimorph. The key enzymatic reaction is fast, employs inexpensive commercially available enzyme, requires minimal work-up, and can therefore easily be performed on a large scale. |