发明名称 |
Stabilized pharmaceutical composition and stabilizing solvent. |
摘要 |
<p>A stabilized pharmaceutical composition containing paclitaxel, teniposide, camptothecin or other antineoplastic agent susceptible to degradation during storage is produced using a solvent system containing a low carboxylate anion content. The solvent system is a mixture of ethanol and a polyoxyethylated castor oil. The polyoxyethylated castor oil is treated with an acid or contacted with alumina to reduce the carboxylate anion content of the solvent. The low carboxylate anion content of the solvent provides extended shelf life and lower amounts of degradation by-products.</p> |
申请公布号 |
EP0645145(A2) |
申请公布日期 |
1995.03.29 |
申请号 |
EP19940115180 |
申请日期 |
1994.09.27 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
AGHARKAR, SHREERHAM NARAHARI;GOGATE, UDAY S.;CAVANAK, THOMAS |
分类号 |
A61K31/337;A61K9/08;A61K9/00;A61K31/335;A61K31/435;A61K31/4375;A61K31/47;A61K31/4738;A61K31/70;A61K31/77;A61K47/10;A61K47/34;A61K47/44;A61P35/00;(IPC1-7):A61K47/44 |
主分类号 |
A61K31/337 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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