SIGNAL PEPTIDE, DNA SEQUENCES CODING FOR THE LATTER, EXPRESSION VECTORS CARRYING ONE OF THESE SEQUENCES, GRAM-NEGATIVE BACTERIA TRANSFORMED BY THESE VECTORS, AND PROCESS FOR THE PERIPLASMIC PRODUCTION OF A POLYPEPTIDE

摘要

The invention relates to a signal peptide of the formula : MXKSTLLLLFLLLCLPSWNAGA in which: A = Alanine M = Methionine C = Cysteine N = Asparagine F = Phenylalanine P = Proline G = Glycine S = Serine K = Lysine T = Threonine L = Leucine W = Tryptophan and X represents a direct bond between M and K, an amino acid selected from the group comprising the 20 amino acids of the genetic code, or a peptide containing 2, 3 or 4 amino acids selected, each independently of the other, from the group comprising the 20 amino acids of the genetic code. Application : Use for the periplasmic production of polypeptides.