PROCESS FOR THE PREPARATION OF 3-AMINO-4-METHOXYACTEANILIDE

摘要

3-Amino-4-methoxy acetanylide of formula (I) is prepared by: dissolving 2,4-diaminoanisol of formula (II) in the solvent which is a mixt. of alcohol and water or a mixt. alcohol and halogenic hydrocarbon, or halogenic hydrocarbon; and reacting the resultant with acetic acid anhydride of formula (III) at -10-30 ≦̸C; and solidifying 3-amino-4-methoxy acetanylide (I) by difference of solubility and filtering the resultant; then neutralizing the reaction solution to reuse continuously. The alcohol and halogenic hydrocarbon is C1-4.