Séquence d'ADN des produits de fusion résultant de la translocation chromosomique récurrente t(11;22) (q24;q12) associée au développement d'un groupe de tumeurs cancéreuses.

摘要

PCT No. PCT/FR93/00494 Sec. 371 Date Jan. 18, 1995 Sec. 102(e) Date Jan. 18, 1995 PCT Filed May 19, 1993 PCT Pub. No. WO93/23549 PCT Pub. Date Nov. 25, 1993Translocations of chromosome 22 are associated with various cancers. Hybrid DNA sequences, having a portion of the Ews gene of chromosome 22 and a portion of either the Hum-Fli-1 gene of chromosome 11, the Erg gene of chromosome 21, or the Atf-1 gene of chromosome 12, are disclosed. Proteins encoded by these hybrid DNAs are disclosed. Diagnosis of specific cancers based on detection of the translocations is disclosed.