发明名称 |
SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES |
摘要 |
The invention comprises novel substituted tetronic acid type compound, 2,4-3(3H,5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for the treatment of a person with AIDS or AIDS related diseases. The compounds may be used in the attempt to retard the further replication of any retrovirus containing the aspartyl protease enzyme. Compounds are represented by formula (1), wherein 3 tautomers of the same structure are shown, R1, R2 and R3 are replaced with various substituents.
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申请公布号 |
CA2168757(A1) |
申请公布日期 |
1995.03.23 |
申请号 |
CA19942168757 |
申请日期 |
1994.09.07 |
申请人 |
UPJOHN COMPANY (THE) |
发明人 |
CHRUSCIEL, ROBERT A.;MAGGIORA, LINDA, L.;THAISRIVONGS, SUVIT;TUSTIN, JAMES M.;SMITH, CLARK W.;TOMMASI, RUBEN A.;ARISTOFF, PAUL A.;SKULNICK, HARVEY I.;HOWE, W. JEFFREY;BUNDY, GORDON L. |
分类号 |
C07D307/33;A61K31/34;A61K31/341;A61K31/41;A61K31/415;A61K31/44;A61K31/443;A61K31/47;A61P31/12;C07D307/60;C07D307/94;C07D405/06;C07D405/12;C07D417/12;C07D473/00;C07D491/10;C07D491/107;(IPC1-7):C07K2/00;C07D409/12;C07D413/12;A61K31/365;C07D473/38;A61K31/395;C07F9/655;A61K31/665 |
主分类号 |
C07D307/33 |
代理机构 |
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