| 发明名称 |
Herpes simplex virus-1 deletion variants and vaccines thereof |
| 摘要 |
<p>Novel Herpes simplex viruses and vaccines based on such novel HSV-1 strains are described. In particular, viruses having a deletion in the terminal portion of RL are provided. The virus can be further modified to express heterologous antigens and also engineered to overproduce HSV Light particles. This is achieved by incorporating a ts mutation into the UL26 gene.</p> |
| 申请公布号 |
AU657731(B2) |
申请公布日期 |
1995.03.23 |
| 申请号 |
AU19920011829 |
申请日期 |
1992.01.30 |
| 申请人 |
SMITHKLINE BEECHAM BIOLOGICALS S.A. |
发明人 |
SUSANNE MOIRA BROWN;ALASDAIR RODERICK MACLEAN |
| 分类号 |
A61K39/245;A61P31/12;A61P31/22;C12N7/00;C12N7/01;C12N7/04;C12N15/09;(IPC1-7):C12N7/04 |
主分类号 |
A61K39/245 |
| 代理机构 |
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