| 摘要 |
This invention relates to the use of nitric oxide adducts to prevent platelet disposition and thrombus formation, on artificial surfaces which come into contact with blood. Suitable nitric oxide adducts include nitroglycerin, sodium nitroprusside, S-nitroso-proteins, Snitrosothiols, long carbon-chain lipophilic S-nitrosothiols, S-nitroso-dithiols, iron-nitrosyl compounds, thionitrates, thionitrites, sydnonimines furoxans, organic nitrates, and nitrosated amino acids. In addition, nitric oxide adducts may also be administered to an animal or human to coat a damaged vascular surface, thereby preventing thrombus formation or platelet deposition on the surface.
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