| 摘要 |
1384894 Trisubstituted thioureas and thioamides ELI LILLY & CO 20 Jan 1972 2777/72 Heading C2C [Also in Division A5] Substituted thioureas having anthelmintic activity of the formula wherein R is naphthyl, phenyl, or phenyl substituted with at least one substituent selected from C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, C 1-4 alkylenedioxy, phenyl, phenoxy, hydroxy, amino, C 1-4 monoalkylamino, C 1-4 dialkylamino, C 1-4 acyl carboxy, C 1-4 alkoxycarbonyl, carbamyl, C 1-4 alkoxycarbonyl amino, C 1-4 acyloxy, C 1-4 alkylsulphonyl, sulpho, sulphamoyl, N-C 1-4 -alkylsulphamoyl, N-C 1-4 dialkylsulphamoyl, halo, halomethyl, dihalomethyl, trihalomethyl, nitro and cyano; R<SP>1</SP> and R<SP>11</SP> when taken separately represent C 3-6 alkyl groups branched at the carbon attached to the nitrogen, or a C 5-6-7 cycloalkyl group, and can be the same or different and R<SP>1</SP> and R<SP>11</SP> taken together with the nitrogen atom to which they are attached represent a moiety of the formula wherein X is one of methyl, ethyl, n-propyl or isopropyl; Y is one of hydrogen or C 1-3 alkyl and n is 2, 3 or 4 are prepared by reacting an isothiocyanate of formula with an alkyl or heterocyclic secondary amine of the formula wherein R, R 1 and R<SP>11</SP> are as defined above. |
