发明名称 |
Amine-derivatized nucleosides and oligonucleosides |
摘要 |
Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2'-, 3'-, 5'-, nucleobase and internucleotide linkage sites. The folate can be attached via the alpha- or gamma-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed. |
申请公布号 |
AU7723394(A) |
申请公布日期 |
1995.03.22 |
申请号 |
AU19940077233 |
申请日期 |
1994.09.02 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
PHILLIP DAN COOK;MUTHIAH MANOHARAN;CHARLES J GUINOSSO |
分类号 |
C12N15/09;A61K47/48;C07H19/067;C07H19/167;C07H21/00;C07H21/02;C07J31/00;C07K14/00;C12N15/113;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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