Use of flavone derivatives for gastroprotection

摘要

The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective amount of a compound having the structure: wherein X and Y are each independently selected from O and S; R1, R2 and R3 are each independently selected from hydrogen, hydroxy, halo, unsubstituted or monosubstituted straight or branched C1-C4 alkanyl, and unsubstituted or substituted straight or branched C1-C4 alkanoxy; and each of R4, R5, R6 and R7 is hydrogen or, if one or more of R1, R2 and R3 is other than hydrogen, each of R4, R5, R6 and R7 is selected from hydrogen, halo, trifluoromethyl, and unsubstituted straight or branched C1-C4 alkanyl.