OPTICALLY ACTIVE 2-PHENYLTHIO-2-CYCLOALKENE DERIVATIVE AND PRODUCTION THEREOF

摘要

PURPOSE:To obtain a novel compound which can be broadly utilized as a stable building block for physiologically active substances such as medicines or agrochemicals. CONSTITUTION:Optically active 2-phenylthio-1-acyloxy-2-cycloalkene of formula I (* means asymmetric carbon atom; R is H, alkylcarbonyl; n is 1 to 4). The compound of the formula I is obtained by ester interchange reaction of a racemic 2-phenylthio-2-cycloalkene-1-ol of formula II with an acylating agent such as a vinyl ester in the presence of a lipase (e.g. from Pseudomonas bacteria) or by hydrolysis of racemic 2-phenylthio-1-acyloxy-2-cycloalkene in the presence of lipase.