发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING HEPATOCYTE INVASION BY MALARIAL SPOROZOITES |
摘要 |
There is provided peptide and mimetic inhibitors for the binding of a circumsporozoite polypeptide to receptors of hepatocytes from malaria-susceptible mammals. Aslo contemplated is a method of inhibiting the binding of a malaria sporozoites to hepatocytes susceptible to sporozoite invasion. A peptide of Region II+ of the circumsporozoite protein is also provided, as is a method of targeting the delivery of substances to hepatocytes.
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申请公布号 |
WO9507094(A1) |
申请公布日期 |
1995.03.16 |
申请号 |
WO1994US10186 |
申请日期 |
1994.09.09 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
CERAMI, CARLA;FREVERT, UTE;SINNIS, PHETORI;NUSSENZWEIG, VICTOR |
分类号 |
A61K38/00;C07K14/445;C07K14/705;C12N15/87;(IPC1-7):A61K38/00;A61K39/015 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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