| 摘要 |
Nucleoside derivatives or nucleoside analogues which comprise a nitrogen-containing base selected from adenine, guanine, cytosine, uracyl and thymine, and which have the general formula I: Nu-O-Fa in which O represents an oxygen atom, Nu is a nucleoside or nucleoside analogue and Fa is an acyl group of a mono-unsaturated C18 to C20 fatty acid, esterified with a hydroxyl group in position 5 of the sugar residue of the nucleoside or with a hydroxyl group of the non-cyclic chain of the nucleoside analogue. Also described are pharmaceutical and veterinary antiviral compositions which include a compound of formula I alone or in combination with a pharmaceutically acceptable vehicle. These derivatives and compositions are useful for treating a human or animal patient suffering from a viral infection and for reducing the infection level.
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