| 摘要 |
<p>A novel disaccharide derivative represented by chemical formula (I), stereochemical isomers and salts thereof, and a pharmaceutical composition containing the same as the active ingredient. The compound has various biological activities such as potent mitogenic activity, adjuvant activity, polyclonal B-cell activating (nonspecific protective) activity, natural killer activity, antitumor activity and antiviral activity, but scarcely has the activity of inducing the production of so-called inflammatory cytokines, such as tumor necrotizing factor (TNF) and IL-1, from macrophages unlike the lipid A and derivatives thereof. Therefore, it is free from noxious effects in which the lipid A and derivatives thereof have been problematic, such as lethal toxicity and pyrogenicity, and hence it is useful not only as immunopotentiator, antitumor agent and antiviral agent, but also as a therapeutic or preventive agent for sepsis, rheumatoid arthritis, and so forth.</p> |
