| 摘要 |
<p>Methods for identifying germinal mutagens, as well as transgene constructs and transgenic animals for use in these methods, are disclosed. Mutagenic agents can be identified using sperm derived from the transgenic animal which will either include a gene encoding a heterologous sperm cell protein, a gene encoding a mutant of the sperm cell protein or a variant gene incapable of transcription unless a mutation occurs. If the animal is exposed to a germinal mutagenic agent, mutations will occur in the sperm cell protein gene, thereby changing the specificity of the gene product and allowing detection of the same.</p> |
