HAPLOTYPE-MATCHED CYTOKINE-SECRETING CELLS AND METHODS OF USING TO STIMULATE AN IMMUNE RESPONSE

摘要

The invention relates to a composition comprising haplotype-matched tumor cells which have been genetically modified to express a cytokine gene and to a composition comprising autologous fibroblasts which have been genetically modified to express a cytokine gene and unmodified tumor cells. The invention also relates to methods for using the haplotype-matched cytokine-secreting cells to stimulate an immune response against a tumor located in the central nervous system of a cancer patient. The invention further relates to a method of inhibiting or preventing the growth of tumor cells in the central nervous system of a patient by immunizing the patient with the haplotypematched cytokine-secreting cells.