发明名称 BLOOD-BRAIN BARRIER TRANSPORTERS OF NEUROLOGICAL AGENTS
摘要 The invention provides method for inducing neuronal precursor cells (NPCs) in vitro and in vivo by contacting NPC with at least one proliferation factor to promote mitosis, survival and/or differentiation of at least one type of NPC and can be used to treat neuronal cell disorders caused by disease, injury, and other neural disorders, as well as methods for transporting molecules across the blood brain barrier by linking them to portions of at least one growth factor to effectively introduce neurological agents capable or incapable of independently crossing the blood brain barrier into the central nervous system. The figure shows the human form of bFGF.
申请公布号 WO9507092(A1) 申请公布日期 1995.03.16
申请号 WO1994US09155 申请日期 1994.08.11
申请人 THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JE 发明人 DICICCO-BLOOM, EMANUEL;BLACK, IRA, B.
分类号 A61K38/00;A61K47/48;C07K14/50;(IPC1-7):A61K38/00;A61K38/02;A61K38/08;A61K38/11;A61K38/21;A61K38/22;A61K38/28;C07K2/00;C07K7/00;C07K7/16;C07K7/18;C07K14/00;C07K14/62;C07K14/70;C07K14/585;C07K14/655;C07K14/675;C07K17/00;C07K17/02;C07K17/06;C07K19/00;C12N15/00;C12N15/09;C12N15/12;C12N15/16;C12N15/17;C12N15/18;C12N15/19;C12N15/21;C12N15/28;C12P21/00;C12P21/02 主分类号 A61K38/00
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