发明名称 2-Piperazinone compounds and their use.
摘要 <p>Compounds of the formula &lt;CHEM&gt; [wherein A represents amidino group or an optionally substituted aminoethyl; R&lt;1&gt;&lt;0&gt; represents one species selected from a group consisting of nitro group, a halogen atom, a lower alkenyl group, a lower alkynyl group, a lower alkyloxycarbonyl group and a group represented by the formula OR&lt;1&gt;&lt;1&gt; (wherein R&lt;1&gt;&lt;1&gt; is hydrogen atom or a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkanoyl group, a carbamoyl group or a methanesulfonyl group, each of which may be substituted; R&lt;1&gt;&lt;2&gt; and R&lt;1&gt;&lt;3&gt; respectively represent hydrogen atom, hydroxyl group, a lower alkoxy group or a halogen atom; X represents hydroxyl group, p-hydroxyphenyl group or an optionally esterified or amidated carboxyl group; Y represents an optionally esterified or amidated carboxyl group; and n denotes 1 or 2], or a salt thereof and agent for inhibiting adhesion of cells, which comprise said compound, and these have more potent and long lasting activities of inhibiting cell-adhesion, thus being useful as an orally administrable anti-thrombotic agent.</p>
申请公布号 EP0643072(A1) 申请公布日期 1995.03.15
申请号 EP19940304241 申请日期 1994.06.13
申请人 TAKEDA CHEMICAL INDUSTRIES, LTD. 发明人 SUGIHARA, HIROSADA;TERASHITA, ZENICHI;FUKUSHI, HIDETO
分类号 C07K5/087;A61K38/00;(IPC1-7):C07K5/08;A61K38/06 主分类号 C07K5/087
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