| 摘要 |
PURPOSE:To obtain a WB968 substance group of new compound useful in the field of medical treatment, having antimicrobial and antitumor activity, by culturing a strain belonging to the genus Chromobacterium, capable of producing a WB968 substance group, in an aqueous nutrient medium under an aerobic condition. CONSTITUTION:A strain [e.g. Chromobacterium violaceum WB968 (FERM-BP-1,968), etc.] belonging to the genus Chromobacterium, capable of producing a WB968 substance group, is cultured in an aqueous nutrient medium under an aerobic condition and the culture product is recovered to give a WB968 substance group including FR900,414 substance, FR901,399 substance and FR901,402 substance. FR900, 414 substance has the following properties. Colorless prism crystal. Neutral substance. Melting point: 167-177 deg.C. Specific rotatory power: [alpha]<23>D=-27 deg. (c=1.0, chloroform:methanol=1:1). Molecular formula C23H34N4O6S2. FR901,399 substance has the following properties. Colorless prism crystal. Neutral substance. Melting point: 225-235 deg.C Specific rotatory power: [alpha]<23>D=--183 deg. (c=0.5). Molecular formula C24H36N4O6S3. FR901,402 substance has the following properties. Colorless powder. Neutral substance. Melting point: 169-179 deg.C. Specific rotatory power: [alpha]<23>D=+3 deg. (c=0.5). Molecular formula C25H38N4O6 S2. |
