| 摘要 |
The invention relates generally to compositions of and methods for obtaining and using a polypeptide, other than B7, that binds to CTLA4, or CD28, or CTLA4Ig, or homologous proteins, and regulates T cell activation. The invention relates as well to the polynucleotides sequences encoding those polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention includes as well, methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering T cell activation for use in diagnostic, drug design and therapeutic applications. |
