METHODS AND COMPOSITIONS FOR BINDING TAU AND MAP2C PROTEINS

摘要

A method of combatting Alzheimer's disease which comprises increases the binding of the tau protein in nerve cells of that subject and/or the binding or MAP2c protein in nerve cells of that subject, to either Apolipoprotein E or an Apolipoprotein E fragment capable of binding tau and/or MAP2c. In one embodiment, the method comprises administering the ApoE or ApoE fragment to the subject; in another embodiment, the method comprises administering to the subject a vector capable of entering nerve cells, which vector then upregulates the expression of an ApoE or an ApoE fragment capable of binding tau and/or MAP2c in nerve cells. Compositions useful for carrying out these methods are also disclosed