发明名称 |
INHIBITION OF BETA AMYLOID BINDING TO GLYCOSAMINOGLYCANS FOR TREATMENT OF ALZHEIMER'S DISEASE |
摘要 |
The present invention relates to compounds that inhibit the binding of glycosaminoglycans and proteoglycans to beta amyloid peptide (A(beta); A beta ), and to compounds that inhibit A beta activation of complement. In one aspect, the compound is a peptide having an amino acid sequence X-X-N-X, in which X is an amino acid with a cationic side chain and N is a neutral amino acid. In another aspect, the compound is a peptide having an amino acid sequence X-X-N-X-Z, in which X is an amino acid with a cationic side chain, N is a neutral amino acid and Z is a neutral amino acid. In yet another aspect, the compound is peptide having an amino acid sequence X1-N-X2-X3, in which at least two of X1, X2, and X3 are independently an amino acid with an anionic side chain and the third X is an amino acid with an anionic side chain or a neutral amino acid and N is independently a neutral amino acid. In yet a further aspect, the compound is an anionic disaccharide. The invention also relates to a method for treating Alzheimer's disease comprising administering a therapeutically effective amount of a compound as described above to a subject suffering from Alzheimer's disease. Pharmaceutical compositions are also provided.
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申请公布号 |
WO9506477(A1) |
申请公布日期 |
1995.03.09 |
申请号 |
WO1994US09853 |
申请日期 |
1994.08.29 |
申请人 |
GLIATECH, INC. |
发明人 |
BRUNDEN, KURT, R.;GUPTA-BANSAL, REKHA;RICHTER-COOK, NANCY, J.;FREDERICKSON, ROBERT, C., A. |
分类号 |
A61K38/00;A61K38/07;A61K38/08;C07K5/103;C07K5/107;C07K5/11;C07K5/113;C07K14/47;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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