| 发明名称 |
METHODS OF PROLONGED SUPPRESSION OF HUMORAL IMMUNITY |
| 摘要 |
Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged.
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| 申请公布号 |
WO9506480(A1) |
申请公布日期 |
1995.03.09 |
| 申请号 |
WO1994US09872 |
申请日期 |
1994.09.02 |
| 申请人 |
TRUSTEES OF DARTMOUTH COLLEGE;NOELLE, RANDOLPH, J. |
发明人 |
NOELLE, RANDOLPH, J. |
| 分类号 |
C12P21/08;A61K35/14;A61K35/18;A61K35/28;A61K38/00;A61K38/11;A61K38/17;A61K39/00;A61K39/395;A61K45/00;A61K49/00;A61P37/00;A61P37/06;C07K14/705;C07K16/28;C07K19/00;G01N33/68;(IPC1-7):A61K39/395 |
主分类号 |
C12P21/08 |
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