发明名称 METHOD OF MARKING EUKARYOTIC CELLS BY THE USE OF A CELL SURFACE RECEPTOR AS A MARKER
摘要 A method of marking a eukaryotic (mammalian) cell by expressing in this cell a nucleic acid, said nucleic acid encoding a cell surface receptor, and by subsequently presenting said receptor at the cell surface, characterized by using a nucleic acid in which the region encoding the intracellular domain of the receptor has been completely or partly deleted or modified in such a way that the receptor presented at the surface cannot, after binding to its binding partner, effect any signal transduction, is effective and usable in gene therapy.
申请公布号 CA2170757(A1) 申请公布日期 1995.03.09
申请号 CA19942170757 申请日期 1994.08.11
申请人 BOEHRINGER MANNHEIM GMBH 发明人 BORDIGNON, CLAUDIO;MAVILIO, FULVIO
分类号 G01N33/53;C07K14/71;C12N5/00;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12R1/91;G01N33/58;G01N33/68;(IPC1-7):C12N15/12;C12N15/18;G01N33/566 主分类号 G01N33/53
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