| 摘要 |
2148373 9506472 PCTABS00036 A method for promoting weight control by treating a subject with a therapeutic amount of one of the .DELTA.5-androstenes listed below to stimulate weight control without affecting appetite or inducing the synthesis of sex hormones. .DELTA.5-Androstenes providing the desired biological activities include: (1) .DELTA.5-Androstene-3.beta.,7.alpha.-diol-17-one, (2) .DELTA.5-Androstene-3.beta.-ol-7,17-dione, (3) .DELTA.5-Androstene-3.beta.,7.alpha.,17.beta.-triol, (4) .DELTA.5-Androstene-3.beta.,17.beta.-diol-7-one, (5) .DELTA.5-Androstene-3.beta.-acetoxy-7,16,17-trione, (6) .DELTA.5-Androstene-3.beta.,16.alpha.-dihydroxy-7,17-dione, (7) .DELTA.5-Androstene-3.beta.-propionoxy-16.beta.-acetoxy-7,17-dione, (8) .DELTA.5-Androstene-3.beta.,7.alpha.,17.beta.-triol-16-one, (9) .DELTA.5-Androstene-3.beta.,17.beta.-diol-7,16-dione, (10) .DELTA.5-Androstene-3.beta.,16.alpha.,17.beta.-triol-7-one and derivatives thereof wherein one or more of the hydroxyl or keto substituents is a group convertible thereto by hydrolysis.
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