IMPROVED PHARMACEUTICAL FORMULATION

摘要

Compositions of matter comprising a substituted cyclodextrin and cytotoxic c ompound, especially cytotoxyc drugs such as antibiotic, anti-fungal and anti-neoplastic drugs are claimed. The compositions cause s ignificantly less ulceration compared to the same formul ation of cytotoxic compound without cyclodextrin compound when extravasated. The compositions may also cause less vascular irritation compared to the same formulation of cytotoxic compound without cyclodextrin when administered intravenously without extravasation. Compositions of matter comprising watersoluble cytotoxic agents, especially anticancer drugs and anti-ulceration effective or anti-i rritation effective amounts of cyclodextrin compounds are also claimed. Methods for r educing the likelihood of ulceration and/or irritation w hen administering the compositions according to the invention are also disclosed and claimed.