发明名称 THIOGLYCEROL DERIVATIVES
摘要 A compound represented by the formula: <IMG> wherein R1 and R2 are the same or different, an acyl group; R3, R4, R6 and R7 are the same or different, hydrogen or an alkyl group; R5 is hydrogen, an alkyl group or a hydroxyl group which may optionally be protected, or R4 and R5 are combined to form a chemical bond; X is a carbonyl group or a sulfonyl group; Y is an amino acid sequence consisting of 1 to 7 amino acid residues which may optionally be protected and having optionally an intervening -SO2NH-; n is an integer of 0 to 2, or a salt thereof. The compound or salt thereof of the present invention possesses immunoenhancing activity and platelet reduction recovery activity, and can be used as a prophylactic/therapeutic agent for leukocytopenia in cancer chemotherapy or radiotherapy, as an immunoenhancing agent in bone marrow transplantation therapy and the treatment of osteomyelodysplasia and aplastic anemia, and as a prophylactic/therapeutic agent for thrombocytopenia.
申请公布号 CA2131639(A1) 申请公布日期 1995.03.09
申请号 CA19942131639 申请日期 1994.09.08
申请人 TAKEDA CHEMICAL INDUSTRIES, LTD. 发明人 AONO, TETSUYA;YUKISHIGE, KOICHI;TANIDA, SEIICHI
分类号 A61K38/00;C07C317/44;C07C323/60;C07D209/46;C07D209/48;C07K5/06;C07K5/072;C07K5/083;C07K5/103;C07K5/11;(IPC1-7):C07K2/00;A61K38/04;A61K31/22;C07C317/28;A61K31/40;C07C323/41;C07D209/44;C07C323/67 主分类号 A61K38/00
代理机构 代理人
主权项
地址