摘要 |
Novel pyridazinamine derivatives of formula <CHEM> wherein R<1> is hydrogen, C1-6alkyl, halo, hydroxy, mercapto, trifluoromethyl, amino, mono or di(C1-6alkyl)amino, cyano, C1-6alkyloxy, aryloxy, arylC1-6alkyloxy, C1-6alkylthio, arylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, arylsulfinyl, aryllsulfonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl or aryl; R<2> and R<3> each independently are hydrogen or C1-6alkyl, or R<2> and R<3> combined may form a bivalent radical of formula -CH=CH-CH=CH- G is a bivalent radical of formula <CHEM> X is O, S, NR<8> or a direct bond; said R<8> being hydrogen or C-6alkyl; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-virals; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions. |
申请人 |
JANSSEN PHARMACEUTICA N.V., BEERSE, BE |
发明人 |
STOKBROEKX, RAYMOND A., B-2340 BEERSE, BE;VAN DER AA, MARCEL J.M., B-2460 KASTERLEE, BE;LUYCKX, MARCEL G.M., B-2440 GEEL, BE;GRAUWELS, GILBERT A.J., B-2300 KESSEL-LO, BE |