| 发明名称 |
INHIBITORS OF TNF-ALPHA SECRETION |
| 摘要 |
Compounds and methods are disclosed that are useful in inhibiting the TNF-.alpha. converting enzyme (TACE) responsible for cleavage of TNF-.alpha. precursor to provide biological active TNF-.alpha.. The compounds employed in the invention are peptidyl derivatives having active groups capable of inhibiting TACE such as hydroxamates, thiols phosphoryls and carboxyls.
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| 申请公布号 |
CA2170158(A1) |
申请公布日期 |
1995.03.02 |
| 申请号 |
CA19942170158 |
申请日期 |
1994.08.19 |
| 申请人 |
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发明人 |
BLACK, ROY A.;FITZNER, JEFFREY N.;SLEATH, PAUL R. |
| 分类号 |
A61K38/00;A61K31/16;A61K31/165;A61K31/66;A61P9/00;A61P29/00;C07C259/06;C07C323/60;C07F9/09;C07K5/02;C07K5/06;C07K5/065;C07K5/068;C07K5/072;C07K5/078;(IPC1-7):C07K5/04;A61K38/05;A61K38/06;A61K31/195;C07C237/22;C07C323/41 |
主分类号 |
A61K38/00 |
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