发明名称 |
Methods of enhancing opiate analgesic potency or detoxifying an opiate addict |
摘要 |
This invention relates to a method of selectively enhancing the analgesic potency of morphine and other clinically used bimodally-acting opioid agonists and simultaneously attenuating development of physical dependence, tolerance and other undesirable side-effects caused by the chronic administration of said bimodally-acting opioid agonists comprising the co-administration of a bimodally-acting opioid agonist which activates inhibitory opioid receptor-mediated functions of neurons in the nociceptive (pain) pathways of the nervous system and an opioid receptor antagonist which selectively inactivates excitatory opioid receptor-mediated side-effects caused by said bimodally-acting opioid agonists. This invention further relates to a method of detoxifying and treating opiate addicts utilizing said opioid receptor antagonists, as well as to a composition comprising an excitatory opioid receptor antagonist of the invention and a bimodally-acting opioid agonist. |
申请公布号 |
AU7474194(A) |
申请公布日期 |
1995.02.28 |
申请号 |
AU19940074741 |
申请日期 |
1994.07.22 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
STANLEY CRAIN;KE-FEI SHEN |
分类号 |
A61K38/22;A61K31/00;A61K31/135;A61K31/485;A61K38/33;A61K45/00;A61K45/06;A61P25/04;A61P25/30;A61P43/00;G01N33/94;G01S7/02 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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