1,4-DIHYDROPYRIDINE CARBOXYLIC ACID ESTER DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

Compounds are described of the formula <IMG> (I) wherein R1 is a nitro or trifluoromethyl group; R2 is a C1-C6 alkyl group; R3 is a pyridyl or pyridyl N-oxide group which may be substituted with halogen, hydroxyl, haloalkyl, C1-C6 alkoxy or C1-C6 alkyl and further may be fused with a benzene or naphthalene ring, said ring being optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, halogen or haloalkyl, and a pharmaceutically acceptable acid addition salt thereof. The compounds of the formula (I) are of vasodilating and blood pressure lowering activities and thus may be useful for the treatment of cardiac diseases, cerebrovascular diseases and hypertension.